New promising weight loss and appetite suppressor molecule

27 07 2006

An international research team has discovered a protein, known as the ciliary neurotrophic factor (CNTF), that acts directly within muscles to increase the body’s metabolism to burn fat and carbohydrates while simultaneously suppressing appetite. This research shows how CNTF activates similar pathways to those stimulated by exercise.

The study, titled “CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK” has been published by Nature Medicine.

This reminds me all the fuss about the ghrelin/leptin hormones, that were initially thought to be the cure-all for weight loss. Later on, they were found to be ineffective because the metabolic pathways leading to obesity are much more complex. But it seems that CNTF overcomes leptin resistance and the effects on fat burning are maintained.

Researchers already think that CNTF could play a key role as a weight loss agent and reducing the risk of metabolic abnormalities associated with excess weight. In the meantime, the best we can do is to stick to physical activity and a healthy diet as lifestyle factors to combat obesity and its related diseases.

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